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Subject Area

Internal Medicine

Article Type

Original Study

Abstract

The objective of this study was to review the role of immunotherapy in treating multiple myeloma (MM). Medline databases (PubMed, Medscape, and ScienceDirect) and all related materials available on the internet from January 1993 to December 2016 were searched. The initial search presented 90 articles of which 29 met inclusion criteria. The articles studied the role of immunotherapy in treating MM. If the studies did not fulfi ll inclusion criteria, they were excluded. Study quality assessment included whether ethics approval was gained, eligibility criteria were specifi ed, appropriate controls were used, adequate information was provided, and whether defi ned assessment measures were undertaken. Each study was reviewed independently; the data obtained were rebuilt into a new language according to the need of the researcher and arranged into different topics through the article. All articles included in this review were human studies. The studies defi ne myeloma as a disorder of differentiated plasma cells. Understanding immune dysregulation in myeloma has led to development of new therapies. Immunotherapy is a promising treatment modality in the management of MM. Many novel immunotherapies such as immunomodulatory drugs, adoptive cell therapy, and monoclonal antibodies were reviewed. Basic research efforts toward better understanding of normal and missing immune surveillance in myeloma have led to development of new strategies and therapies that require the engagement of the immune system. Many novel immunotherapy strategies such as immunomodulatory drugs, adoptive cell therapy, and monoclonal antibodies are currently under investigation in clinical trials.

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