Association between TSPAN15 (rs78707713) and SLC44A2 (rs2288904) Genetic Polymorphisms and Venous Thromboembolism in Cancer Patients

Authors

Shaimaa El Sayed Ramadan Genena, Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Menoufia University, Menoufia Governorate, Egypt
Alshimaa Mahmoud Alhanafy, Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Menoufia University, Menoufia Governorate, Egypt
Suzan Foad Omar, Department of Radiodiagnosis, Faculty of Medicine, Menoufia University, Menoufia Governorate, Egypt
Manal Monir Mansour, Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Menoufia Governorate, Egypt
Mona Abdelhamid Mohammed Kora, Department of Pathology, Faculty of Medicine, Menoufia University, Menoufia Governorate, Egypt
Mohamed Abdelhafez, Department of Internal medicine, Hematology unit, Faculty of Medicine, Menoufia University, Menoufia Governorate, Egypt
Marwa Mohammed Ibrahim Mohammed Khalil, Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Menoufia University, Menoufia Governorate, EgyptFollow

Subject Area

Genetics

Document Type

Original Study

Abstract

Objectives: to assess the relationship between TSPAN15 and SLC44A2 polymorphisms and VTE in cancer patients was evaluated with correlation to PROTECHT scoring system and survival data. Background: Although venous thromboembolism (VTE) is common in cancer patients, the underlying mechanisms are complex and poorly understood. .Methods: This study enrolled two groups: 50 VTE-cancer patients in group I and 50 cancer patients with no VTE in group II. Full history, general examination, histopathological diagnosis, and clinical stage were recorded. Complete blood count, coagulation profile, and analysis of TSPAN15 (rs78707713) and SLC44A2 (rs2288904) SNPs by polymerase chain reaction technique were done. Radiological examinations was done according to the clinical scenario. PROTECHT score and survival analysis were performed. Results: VTE-cancer patients had high grade cancer, increased incidence of metastasis with shorter progression-free survival (PFS) versus those without VTE. Partial immobilization, hospitalization and gemcitabine-based chemotherapy showed a significant relationship with VTE in cancer patients. SLC44A2 and TSPAN15 mutant alleles were more prevalent in group I. SLC44A2 (AG+GG) and TSPAN15 (CC) genotypes were identified as VTE independent risk factors. Conclusion: VTE is associated with higher tumor grades and metastatic disease, and it is linked to shorter PFS in cancer patients. Screening of SLC44A2 (rs2288904) and TSPAN15 (rs78707713) genetic variants may enhance the ability to predict VTE risk in cancer patients.

Recommended Citation

Genena, Shaimaa El Sayed Ramadan; Alhanafy, Alshimaa Mahmoud; Omar, Suzan Foad; Mansour, Manal Monir; Kora, Mona Abdelhamid Mohammed; Abdelhafez, Mohamed; and Khalil, Marwa Mohammed Ibrahim Mohammed (2024) "Association between TSPAN15 (rs78707713) and SLC44A2 (rs2288904) Genetic Polymorphisms and Venous Thromboembolism in Cancer Patients," Menoufia Medical Journal: Vol. 37: Iss. 1, Article 11.
DOI: https://doi.org/10.59204/2314-6788.1119