Article Type

Original Study


Objectives The aim of this study was to evaluate the role of transrectal ultrasonography (TRUS)-guided biopsy in the detection of prostate cancer in patients on the basis of elevated prostate-specific antigen levels and abnormal digital rectal examination (DRE) results. Background The TRUS-guided biopsy technique was regarded as the golden standard method for diagnosis of prostate cancer. This study aimed to identify an appropriate prostate biopsy protocol for the detection of prostate cancer. Materials and methods This study included 30 patients having symptoms suggestive of prostatic diseases. All these patients were subjected to DRE, serum prostate-specific antigen testing, transabdominal ultrasound examination and TRUS, as well as biopsy taking. Results Among the 30 patients studied, final diagnosis by TRUS-guided biopsy revealed benign prostatic hyperplasia in 16 patients (53.3%), which was the most common pathology, precancerous lesions in seven patients, prostatitis in four patients (13.3%), and prostatic adenocarcinoma in three patients (10%). Among the patients with precancerous lesions, five (16.7%) had prostatic intraepithelial neoplasia and two (6.7%) had atypical adenomatous hyperplasia. Conclusion Correlation of prostate-specific antigen levels and findings from DRE and TRUS images with biopsy results is considered the most useful method to improve sensitivity of prostate cancer detection.