Article Type

Original Study


Objectives To clarify the role of leptin in the pathogenesis of psoriasis. Background Psoriasis is considered a systemic disease with significant cardiovascular comorbidity. Studies suggested that hyperleptinemia might play an important role in obesity-associated cardiovascular diseases, including atherosclerosis. Methods The study included 40 consecutive patients with plaque-type psoriasis and 10 control individuals The patients were recruited from the Dermatology Outpatient Clinic, Faculty of Medicine, Menoufia University, and Shibin El Kom Educational Hospital. All the patients underwent were performed: Complete history taking, clinical examination, laboratory investigation to determine leptin concentration using solidphase ELISA and skin biopsies. Results The serum leptin level was significantly higher in psoriatic patients than in controls. There were statistically significant correlations between the serum leptin level and PASI score and duration of the disease, but insignificant correlations with respect to other clinical and histopathological parameters. Conclusion The study supports the view that leptin may be involved in the pathogenesis of psoriasis in overweight individuals.