Article Type



Objective The aim of the work was to highlight toll-like receptors and their therapeutic use in different diseases. Data sources Data were obtained from medical text books, medical journals, and medical websites, which had updated investigations with the key word (toll-like receptors) in the title of the papers. Study selection Selection was carried out by supervisors for studying toll-like receptors and their clinical significance. Data extraction Special search was carried out for the key word toll-like receptors in the title of the papers, and extraction was made, including assessment of quality and validity of papers that met with the prior criteria described in the review. Data synthesis The main result of the review and each study was reviewed independently. The obtained data were translated into a new language based on the need of the researcher and have been presented in various sections throughout the article. Recent findings We now know that innate immunity plays an important role in the initiation of an immune response that follows the activation of antigen specific acquired immunity. A complete understanding of the mechanisms of innate immunity will be helpful for the future development of innovative therapies for the treatment of infectious diseases, cancer, allergies, and renal diseases.