Article Type

Original Study


Objectives The objective of this study was to assess the rate of bacteremia, the most common bacteria, its antibiotic sensitivity pattern, and the role of immunity in its occurrence in diabetic patients. Background Bacteremia constitutes the most severe end of the spectrum of frequent community-acquired infections, and the prevalence, and thus disease burden, of bacteremia has increased during the past decades analogous with diabetes. Materials and methods A total of 160 individuals (93 male and 67 female with a mean age of 48.0 ± 9.7 years) were divided into the following groups: 60 diabetics with infections (group I), 70 nondiabetics with infections (group II), and 30 apparently healthy persons as controls; the studied groups were subjected to full medical history, clinical examination, and bacteriological examination of blood, antibiotic sensitivity pattern for the isolated microorganisms, measurement of serum IgM, IgG by radioimmunodiffusion, and T lymphocyte level by flow cytometry. Results The rate of bacteremia in group I was significantly higher than in group II (P = 0.007), the level of IgM and CD3 in group I was significantly higher than in group II (P = 0.003), and total leucocytic count in group I was significantly higher than in group II (P < 0.001). Staphylococcus aureus was the most common organism isolated form blood of diabetic patients, and 90.9% of them were sensitive to amikacin, followed by imipenem, vancomycin, and ceftriaxone (81.8%). Conclusion Diabetes increases the risk of exposure to bacteremia and affects the immune response to bacteremia.