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Article Type

Original Study

Abstract

Objective The aim of the study is to evaluate the relationship between renal functions and plasma vitamin C concentration in nondiabetic and diabetic patients with chronic kidney disease. Background A decreased plasma level of vitamin C has been reported to be associated with an increased risk of cardiovascular morbidity and mortality. Here, we sought to determine the vitamin C status of patients with chronic kidney disease and the pathophysiological role of vitamin C in these patients. Patients and methods A total of 50 patients were included in the study and classified into two groups: group I, patients with chronic kidney disease with diabetes and group II, patients with chronic kidney disease without diabetes. The relationship between renal function and plasma vitamin C concentration was evaluated, as well as the effect of diabetes on this relationship. Results Statistical comparison revealed a significant statistical increase in the mean value of vitamin C level in the group II compared with group I (P ≤ 0.001). Also, there was a significant positive correlation between vitamin C level and both weight and estimated glomerular filtration rate in the patients, whereas there was a significant negative correlation between vitamin C level and each of serum creatinine level, blood urea level, albumin–creatinine ratio, and glycosylated hemoglobin level in the patients. Conclusion Renal dysfunction was associated with a decreased level of plasma vitamin C in patients with chronic kidney disease. Diabetic patients showed a lower level of vitamin C at any given estimated glomerular filtration rate compared with nondiabetic patients.

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