Article Type

Original Study


Objectives The aim of this article was to determine the role of mean platelet volume (MPV) and uric acid (UA) level in the diagnosis of neonatal sepsis. Background MPV is a measure of platelet volume; larger platelets have more granules. It reveals the presence of inflammatory burden and disease activity in many diseases. UA is one of the most important antioxidants in human biological fluids and is responsible for neutralizing more than 50% of the free radicals in human blood. For this reason, it was thought that the antioxidant effects of UA could increase the life expectancy and/or reduce the incidence of malignancy. Patients and methods This study was conducted on 80 newborns divided into two groups: group 1 included 40 newborns diagnosed with neonatal sepsis and group 2 included 40 healthy newborns assigned as controls. All patients in the study were subjected to adequate assessment of history, full clinical examination, complete blood count including MPV, C-reactive protein, blood culture, and serum UA level at the time of diagnosis of sepsis. Results Septic neonates showed statistically higher values of MPV and statistically lower levels of serum UA. Area under curve values for MPV and UA were 0.65.4 (P = 0.01) and 0.69 (P = 0.001), respectively. The diagnostic cut-off values of MPV and UA for neonatal sepsis were 7.85 fl and 5.8 mg/dl, respectively. Conclusion MPV and UA should be assessed in the early diagnosis of neonatal sepsis.