Article Type

Original Study


Objective The aim of this study was to evaluate reticulated platelets (RP) as a predicting factor of the outcome in acute coronary syndrome (ACS) patients. Background ACS is due to rupture of an arterial plaque. RPs are newly formed platelets with a greater mass, residual amount of RNA, and an increased prothrombotic potential compared with mature platelets. In this study, the RPs were investigated as participating factors in the pathogenesis of ACS. Patients and methods A total of 50 patients with ACS [33 acute myocardial infarction (AMI) and 17 unstable angina] and 15 clinically healthy individuals as controls were investigated for RPs by means of flowcytometry analysis. Results RPs were highly significantly increased in AMI than in unstable angina and controls. Conclusion High levels of RPs are found in ACS patients and it can be used as a predictor for adverse outcome. Moreover, it can participate in the development of AMI due to its high thrombogenic potential.