Article Type

Original Study


Objective The aim of this study was to investigate the differences between type I and type II endometrial carcinoma (EC) as regards relevant clinicopathological features. Background EC is the most frequent gynecological malignancy in the USA accounting for 3% of deaths yearly. However, in Egypt, it accounts for 1.6% of total female cancers, ranking 13th. It is the third most common gynecological cancer after cancer of the ovary and the cervix constituting about 23%. Methods Data were collected from the archive of Department of Pathology, Menoufia University, during the period from 2010 to 2014. The slides presented were examined to meet the inclusion criteria. The slides were examined to differentiate between type I and type II EC. If the slides did not fulfill the inclusion criteria, they were excluded. Study quality assessment included adequate information and defined assessment measures. All slides were examined and comparisons were made between type I and type II EC and the results were tabulated. Results Forty-nine of 67 (73.1%) cases were of type I EC, whereas 18 (26.9%) cases were of type II EC. High grade (100%), advanced stage (55.6%), high mitotic count (mean ± SD: 6.72 ± 2.49), and low apoptotic count (mean ± SD: 8.28 ± 10.18) were in favor of type II EC. Conclusion Type I EC is more frequent compared with type II. Type II EC is more aggressive compared with type I and is manifested by presentation at high grade, advanced stage, high mitoses, and low apoptotic count.