Article Type

Original Study


Objective The aim of this review was to present the current trends and methodologies of the use of early goal-directed therapy (EGDT) and its efficacy in patients in severe sepsis and septic shock. Data sources Data were obtained from Medline databases (PubMed, Medscape, and Science Direct) and from materials available on the Internet from the start date of each database to February 2017. Data selection The selected articles are systematic reviews and experimental studies that address EGDT in severe sepsis and septic shock. Data extraction Extraction was performed according to the validity, quality, and originality of the selected reviews and studies that fulfilled the previous criteria; in addition, the focus was on studies that present the latest or the most updated findings on application of EGDT. Data synthesis Each review and study was reviewed. The layout was selected to present a wide range of data including the most recent findings on this subject. Significant data were collected; thus, a structured review was performed. Results Most of studies conclude that EGDT is very important and its use markedly decreases mortality and morbidity in patients with severe sepsis and septic shock. Conclusion The main conclusion of the reviews and studies that were presented in the current research paper is that the use of EGDT in severe sepsis and septic shock reduces the length of hospital stay and reduces the hospital mortality rate in selected patients.