Subject Area


Document Type

Original Study


Objectives:To correlate between the breast ultrasound imaging features and molecular subtypes of breast cancer and to assess the predictive value of their correlation

Background:Molecular subtyping of breast cancer has become the standard of care in breast cancer management. Survival, pattern of recurrence, and treatment response vary between different molecular subtypes.

Methods: This prospective cross-sectional study included all consecutive female patients referred to the Radiology Department from January 2020 to April 2022who underwent breast ultrasound and surgical excision followed by histopathology and immunohistochemistry (IHC) of the surgical specimen.

Results:A total of 105 patients with pathologically proven breast cancer were included. Multifocal tumours with calcifications were strongly associated with human epidermal growth receptor 2 positive (HER2+)tumours with a P value of

Conclusion: Certain ultrasound imaging characteristics like tumour margins, posterior acoustic features, vascularity on colour Doppler and calcifications are highly predictive of certain molecular subtypes of breast cancer further expanding the role of ultrasound and potentially enhancing patient outcome by accelerating diagnosis and treatment.