Background: Temporal lobe epilepsy (TLE) is the most common type of intractable and partial epilepsies. The only standard treatment for seizure-free status with manifest TLE is surgical which includes amygdala-hippocampectomy. The majority of temporal lobe seizures originate in the mesial temporal structures, primarily in the hippocampus, para hippocampal gyrus and amygdala.
Objectives: To compare lateralizing ability of Magnetic resonance spectroscopy and Diffusion tensor imaging in patients with temporal lobe epilepsy.
Methods: The study recruited 50 participant assigned into two groups: the first group included 25 epileptic cases and the second group included 25normal controls. Age showed a mean ± SD of 24.22 ± 9.7 years. All participants subjected to the following, clinical assessment, EEG, radiological assessment including: MRI epilepsy protocol, MRS and DTI. Data were collected, revised, then extracted and coded in excel file.
Results: MR spectroscopy has demonstrated consistent metabolic abnormalities in partial seizures. Semiology showed the highest and the most perfect diagnostic ability indices for epilepsy (100%), followed by MRS (accuracy = 92%), and DTI difference ≥ 0.014 (accuracy = 86%).
Semiology showed the highest and the most perfect diagnostic ability indices for epilepsy (100%).
MR Spectroscopy is a highly sensitive tool to predict the TLE (accuracy = 92%).
DTI difference ≥ 0.014 (accuracy = 86%) so it has high value also in diagnosis of temporal lobe epilepsy.
El-Kapany, Rasha Ali; Al-Ahmar, Ibrahim Al-Sayed; Elkholy, Mona Sabry; Aly, Rasha Abdelhafiz; and Hassan, Ahmed Ali Saad Ali
"Lateralizing Ability of Magnetic Resonance Spectroscopy and Diffusion Tensor imaging in Temporal Lobe Epilepsy,"
Menoufia Medical Journal: Vol. 36:
1, Article 12.