Plasma pentraxin 3 as novel diagnostic marker in nonalcoholic fatty liver disease

Authors

El Sayed Ibrahium El Shayeb, Department of Internal Medicine, Gastroenterology and Hepatology, Faculty of Medicine Menoufia University, Egypt
Eman Masoud Abd El Gayed, Department of Medical Biochemistry & Molecular Biology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
Janet George Hanna Sedhom, Department of Internal Medicine, Gastroenterology and Hepatology, Faculty of Medicine Menoufia University, EgyptFollow
Abd EL Naser Abdel Atty Gadallah, Department of Internal Medicine, Gastroenterology and Hepatology, Faculty of Medicine Menoufia University, Egypt

Subject Area

Internal Medicine

Article Type

Original Study

Abstract

Objective:To assess the role of plasma pentraxin-3 in Nonalcoholic fatty liver disease (NAFLD)among Egyptian patients.

Background:Nonalcoholic fatty liver disease represents a serious health concern and will amount to significant burden on health care systems.

Methods:a randomised controlled trial was conducted on 90 participants at outpatient clinic and inpatient internal medicine departments, Menoufia University Hospitals. All included participants were dividedinto 70 patients of NAFLD and 20 control healthy persons.blood pressure, weight, height, body mass index, waist circumference, fasting blood glucose,prothrombin time, activated partial prothrombin time, international normalised ratio, liver enzymes, lipid profile and pentraxin-3 level were investigated.

Results:there were significantly higher of pentraxin-3 levels in both of steatohepatitis and steatosis groups than the control group (p2.7745 with sensitivity 97% and specificity 75% and area under the curve 98%.

Conclusion: Patients with steatohepatitis and steatosis showed significant increased pentraxin-3 levels with significant positive correlation between PTX-3 levels, BMI, and cholesterol levels compared to control group.

Recommended Citation

El Shayeb, El Sayed Ibrahium; El Gayed, Eman Masoud Abd; Sedhom, Janet George Hanna; and Gadallah, Abd EL Naser Abdel Atty (2023) "Plasma pentraxin 3 as novel diagnostic marker in nonalcoholic fatty liver disease," Menoufia Medical Journal: Vol. 36: Iss. 1, Article 13.
DOI: https://doi.org/10.59204/2314-6788.1012