Subject Area


Document Type

Original Study


Objectives: to evaluate the potential antidepressant effect of rutin in diabetic rats and the assumed underlying mechanisms involved.

Background: Depression is a common behavioral disorder among diabetic patients. Oxidative stress and inflammation are strongly involved in pathophysiology of diabetes induced depression. Rutin is major flavonoid that is proved to have neuroprotective effect through antioxidant and anti-inflammatory effects.

Methods: Twenty four male Wistar rats were distributed (8/group) into control, diabetic and diabetic+Rutin groups. The depressive like behavior of the animals was conducted by forced swim test (FST). Fasting serum glucose, serum glycosylated hemoglobin A1c (Hb A1c), malondialdehyde (MDA), total antioxidant capacity, tumour necrosis factor-α (TNF-α), and interleukin 1β (IL-1β) were measured in addition, hippocampal serotonin and hippocampal BDNF were also assessed.

Results: Diabetic group showed significant increase in fasting serum levels of glucose, HbA1c, MDA, TNF-α and IL-1β and significant decrease in serum total antioxidant capacity, hippocampal serotonin and hippocampal BDNF levels when compared to control group as well as increased immobility time and decrease latency to immobility of FST compared to control group. Rutin attenuated diabetes-induced depression through improving glycemic state, oxidative stress biomarkers, inflammatory mediators, and increased hippocampal serotonin and hippocampal BDNF levels.

Conclusion: Rutin exerted antidepressant effect in diabetic rats via antioxidant, anti-inflammatory effects, and increased serotonin and BDNF levels.