Subject Area


Article Type

Original Study


Objectives: To evaluate the effect of milk temperature either at warm temperatures closer to freshly expressed breast milk versus at room temperature on feeding tolerance in premature infants.


Feeding intolerance (FI) is frequent among preterm infants in neonatal intensive care units (NICUs). It has several symptoms and is attributed to many factors including milk temperature.


This prospective cohort study included 70 preterm neonates divided into 2 groups; group I included 35 preterm neonates fed with milk at 22– 24°C, closer to room temperature, group II: 35 preterm neonates fed with milk at 32– 34°C, closer to freshly expressed breast milk. All the included subjects underwent full history taking, examination, and laboratory investigations.


Apnea and anti-reflux treatment were statistically decreased in group II who were fed milk at body temperature (p= 0.01). While the difference regarding feeding tolerance between the two groups was statistically insignificant (p>0.05). Subgroup analysis revealed that the difference between the subgroups was also statistically insignificant (p>0.05).


Feeding preterm infants milk at body temperature versus room temperature milk had significantly reduced episodes of apnea and anti-reflux treatment.