Document Type

Special Issue Article


Background: Myocardial infarction (MI) is a severe form of coronary artery disease (CAD) with a high incidence of morbidity and death. TRAF3IP2 (rs 13210247) gene polymorphism may influence the occurrence and pathogenesis of MI. Objective: To study the association of (TRAF3IP2) rs 13210247 (ACT1) gene polymorphism and serum level of CXC ligand 1 (CXCL1), with the MI risk. Patients and methods: This study was conducted on 70 MI patients, and a control group of another 70 healthy participants. All Participants were subjected to full history taking, complete clinical examinations and all required laboratory investigations [triglycerides (TG), LDL-c, HDL-c, total cholesterol (TC), troponin I (TnI) and creatinine kinase-MB (CK-MB)], measuring serum level of CXCL1 and assessment of ACT1 ( TRAF3IP2) rs 13210247 gene polymorphism was done by using real time PCR. Results: TC, LDL-c, TG CK-MB, serum creatinine, TnI and CXCL1 had significantly increased in MI group than controls. Increased CXCL1 (992.9 ± 311 versus 30.9 ± 34.4, p=