Association of Tumor necrosis factor Receptor-Associated Factor 3 Interacting Protein 2 (TRAF3IP2) rs 13210247 gene polymorphism and serum level of CXC ligand 1 (CXCL1) with the risk of Myocardial Infarction

Authors

Eman Masoud Abd El Gayed, Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Menoufia University, Egypt.Follow
Eman S. El Deen Arafat, Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Menoufia University, Egypt.
Mohammed Elhelbawy, Department of Clinical pathology, Faculty of Medicine, Menoufia University, Egypt
Mohamed Yahia Abdel Khalik, Cardiology Department, Faculty of Medicine, University of Menoufia, Egypt
Yasser Abdel Sattar Elghobashy, Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Menoufia University, Egypt

Article Type

Special Issue Article

Abstract

Background: Myocardial infarction (MI) is a severe form of coronary artery disease (CAD) with a high incidence of morbidity and death. TRAF3IP2 (rs 13210247) gene polymorphism may influence the occurrence and pathogenesis of MI. Objective: To study the association of (TRAF3IP2) rs 13210247 (ACT1) gene polymorphism and serum level of CXC ligand 1 (CXCL1), with the MI risk. Patients and methods: This study was conducted on 70 MI patients, and a control group of another 70 healthy participants. All Participants were subjected to full history taking, complete clinical examinations and all required laboratory investigations [triglycerides (TG), LDL-c, HDL-c, total cholesterol (TC), troponin I (TnI) and creatinine kinase-MB (CK-MB)], measuring serum level of CXCL1 and assessment of ACT1 ( TRAF3IP2) rs 13210247 gene polymorphism was done by using real time PCR. Results: TC, LDL-c, TG CK-MB, serum creatinine, TnI and CXCL1 had significantly increased in MI group than controls. Increased CXCL1 (992.9 ± 311 versus 30.9 ± 34.4, p=

Recommended Citation

Gayed, Eman Masoud Abd El; Arafat, Eman S. El Deen; Elhelbawy, Mohammed; Khalik, Mohamed Yahia Abdel; and Elghobashy, Yasser Abdel Sattar (2023) "Association of Tumor necrosis factor Receptor-Associated Factor 3 Interacting Protein 2 (TRAF3IP2) rs 13210247 gene polymorphism and serum level of CXC ligand 1 (CXCL1) with the risk of Myocardial Infarction," Menoufia Medical Journal: Vol. 36: Iss. 2, Article 14.
DOI: https://doi.org/10.59204/2314-6788.1084