Subject Area


Article Type

Original Study



To explore the effect of adding vitamin C, thiamine, and hydrocortisone to traditional treatment in treatment of sepsis.


Sepsis is a life-threatening syndrome of a dysregulated host response to infection. Sepsis remains a significant cause of morbidity and mortality, despite advances in diagnosis and treatment. Using vitamin C, thiamine, and hydrocortisone to traditional treatment (Marik protocol) may play a key role in treatment of sepsis.

Patients and methods

This case–controlled study was conducted on 44 Egyptian patients diagnosed with sepsis according to sequential organ-failure assessment score then divided into two equal groups, half of them treated with traditional treatment with sepsis for 5 days and the other half treated with Marik treatment that added on traditional treatment for 5 days, all patients undergo quick sequential organ-failure assessment, daily also close-monitoring vital data and sepsis markers (C-reactive protein, lactate, and procalcitonin), the need to mechanical ventilation and vasopressors, and then prognosis.


There was a statistically significant improvement in the level of sepsis markers and vital data in patients receiving Marik treatment. Also, there was a highly statistically significant difference between both treatments in using mechanical ventilation, vasopressors, and prognosis of patients.


Marik treatment added to traditional treatment has a superiority over traditional treatment of sepsis. We recommended that addition of vitamin C, thiamine, and hydrocortisone to the traditional treatment of sepsis seems to improve the prognosis of patients with sepsis.