Subject Area


Article Type

Original Study


Objectives: The current study was designed to evaluate the effect of pregabalin premedication in conjunction with dexmedetomidine on sedation during cataract surgery done under topical anesthesia. Background: Although dexmedetomidine can promote optimal sedation, there are still concerns about its side effects. Methods: Sixty patients undergoing cataract surgery under topical anesthesia were randomly allocated into two equal groups. One hour before the procedure, the patients in the pregabalin group received 150 mg pregabalin, while those in the control group received placebo capsules. All patients were sedated with a dexmedetomidine infusion. Sedation score, verbal pain score (VPS), oxygen saturation, respiratory rate, hemodynamics, side effects, intraoperative and postoperative analgesic requirements, total dexmedetomidine dose, and patients’ and surgeons' satisfaction scores were recorded. Results: There is significantly lower VPS and higher sedation scores in the pregabalin group than in the control group during the intraoperative and postoperative times (P < 0.001). The total dexmedetomidine needs in the pregabalin group were significantly lower than the control group (P < 0.001) with median [IQR]; 83.5 µg [74 to 93] and 99 µg [85 to 107] respectively. Intraoperative and postoperative analgesic needs were significantly lower in the pregabalin group (P < 0.001). Conclusion: Pregabalin premedication in conjunction with dexmedetomidine for conscious sedation in patients undergoing cataract surgery under topical anesthesia enhances the sedative and analgesic effects while reducing dexmedetomidine dose and side effects.