Breast carcinoma is the commonest cause of cancer-linked mortality among women worldwide.
To assess the expression of Lin28, MUC1, and Lipocalin2 by immunohistochemistry in breast carcinoma and to investigate their correlation with clinicopathological features and patient survival.
This cross-sectional study was performed on 60formalin-fixed, paraffin-embedded tissue blocks of breast carcinoma cases. Expression patterns of Lin28, MUC1, and Lipocalin2 in breast carcinoma were investigated regarding their relation with patients̕5-year survival rate.
Lin28, MUC1, and Lipocalin2 expressions were found in 55, 75, and 45% of cases, respectively. Lin28 was located in the cytoplasm, MUC1 showed membranous expression,whereas Lipocalin2 was found in both nuclei and cytoplasm of malignant cells. High expression of Lin28 and MUC1 and low expression of
Lipocalin2 were correlated with poor clinicopathological features and unfavorable overall survival in patients with breast carcinoma.
Lin28 and MUC1 overexpression and low Lipocalin2 expression in breast carcinoma can help in the prediction of tumor prognostication, and it can lead to the selection of patients for better treatments.
Elaidy, Noha F.; Mosely, Marwa M.El; Elwan, Amira; Embaby, Ahmed; and Abdelrahman, Doaa I.
"Prognosticimplications of Lin28, MUC1, and Lipocalin2 immunoexpression in breast cancer,"
Menoufia Medical Journal: Vol. 36:
2, Article 9.