Subject Area


Document Type

Original Study


Objective: To analyze the surge of invasive fungal rhinosinusitis reported during the Covid-19 pandemic to highlight aspects of disease and outcome of our approach with these cases.

Background: Invasive fungal rhinosinusitis is the most severe form of sinusitis affecting immunocompromised patients. Therefore, prompt management is mandatory to improve survival.

Methods: In a prospective cohort study, we included 40 cases of acute invasive fungal rhinosinusitis who attended to Otorhinolaryngology department between May 2021 and October 2021. We assessed the patient clinically and radiologically. We collected data about sociodemographic features including sex, age, comorbidities, post COVID infection, received treatment, and history of steroid use. Patients were followed up after they received treatment, and survival analysis was conducted.

Results: All patients witnessed sino-nasal affection, the most commonly reported complication was orbital involvement (87.5%), followed by intracranial involvement (20%). All patients received medical treatment; with the majority of them received Amphotericin B , additionally, all patients underwent surgical treatment; with the majority of them underwent both maxillectomy and endoscopic debridement . Fortunately, more than three fourths of them survived (87.5%).

Conclusion: Mucormycosis can be a fatal condition unless managed promptly. Comorbid conditions and associated complications are the main determinants of mortality. Early medical treatment accompanied by surgical treatment enhances the survival rate.