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Subject Area

Biochemistry

Document Type

Original Study

Abstract

Objectives: to investigate the relationship between breast cancer in Egyptian females and the Tissue Inhibitor of Matrix Metalloproteinase-2 (TIMP2) gene polymorphism. Background: breast cancer is one of the most prelevant cancers, that has significant potential for invasion and metastasis. Under expression of TIMP-2 activity that is caused by genetic polymorphism in TIMP-2 gene, might impact to development and pathway of breast cancer. Methods: This work was performed on two hundreds individuals (one hundred female patients with breast cancer matched in age with one hundred healthy female controls). TIMP-2 gene (rs2277698) SNP was genotyped by TaqMan allelic discrimination using Real-Time PCR System. Results: Breast cancer patients had significantly higher frequencies of the TIMP2 rs2277698 TT genotype (p=0.004, OR [95%CI]; 4.007(1.548 - 10.371) and T allele (p=0.001, OR [95%CI]; 2.156(1.392 - 3.339). There was a considerable difference under the dominant model regarding side of the tumor and menopausal status in the rs2277698 genotype distribution (p=0.002). Conclusion: According to our research, TIMP-2 rs2277698 TT genotype and T allele were related with a greater risk of developing carcinoma of the breast. Additionally, menopausal condition is accompanying with the genetic variant rs2277698.

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