Association Between Tissue Inhibitor of Matrix Metalloproteinase-2 Gene Polymorphism And Breast Cancer In Egyptian Females

Authors

Manal Abd El Monem Ellaithy, Menoufia University, Medical Biochemisrtry and Molecular Biology Department, Egypt
Mohamed Soliman M. Rizk, Menoufia University, Medical Biochemisrtry and Molecular Biology Department, Egypt
Hatem Mahmoud El Sebaie, Menoufia University, Medical Biochemisrtry and Molecular Biology Department, Egypt
Amira Hegazy, Menoufia University, Clinical Oncology and Nuclear Medicine Department, Egypt
Fatma Mahmoud Kotb Omran, Menoufia University, Medical Biochemisrtry and Molecular Biology Department, EgyptFollow
Eman Salah-Eldeen El Sayed Arafat, Menoufia University, Medical Biochemisrtry and Molecular Biology Department, Egypt

Subject Area

Biochemistry

Article Type

Original Study

Abstract

Objectives: to investigate the relationship between breast cancer in Egyptian females and the Tissue Inhibitor of Matrix Metalloproteinase-2 (TIMP2) gene polymorphism. Background: breast cancer is one of the most prelevant cancers, that has significant potential for invasion and metastasis. Under expression of TIMP-2 activity that is caused by genetic polymorphism in TIMP-2 gene, might impact to development and pathway of breast cancer. Methods: This work was performed on two hundreds individuals (one hundred female patients with breast cancer matched in age with one hundred healthy female controls). TIMP-2 gene (rs2277698) SNP was genotyped by TaqMan allelic discrimination using Real-Time PCR System. Results: Breast cancer patients had significantly higher frequencies of the TIMP2 rs2277698 TT genotype (p=0.004, OR [95%CI]; 4.007(1.548 - 10.371) and T allele (p=0.001, OR [95%CI]; 2.156(1.392 - 3.339). There was a considerable difference under the dominant model regarding side of the tumor and menopausal status in the rs2277698 genotype distribution (p=0.002). Conclusion: According to our research, TIMP-2 rs2277698 TT genotype and T allele were related with a greater risk of developing carcinoma of the breast. Additionally, menopausal condition is accompanying with the genetic variant rs2277698.

Recommended Citation

Ellaithy, Manal Abd El Monem; Rizk, Mohamed Soliman M.; Sebaie, Hatem Mahmoud El; Hegazy, Amira; Omran, Fatma Mahmoud Kotb; and Arafat, Eman Salah-Eldeen El Sayed (2023) "Association Between Tissue Inhibitor of Matrix Metalloproteinase-2 Gene Polymorphism And Breast Cancer In Egyptian Females," Menoufia Medical Journal: Vol. 36: Iss. 3, Article 20.
DOI: https://doi.org/10.59204/2314-6788.1029