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Subject Area

Pediatrics

Article Type

Original Study

Abstract

Objectives: To study the relation between angiotensin I converting enzyme (ACE) and receptor for advanced glycation end products (RAGE) genes in children with type 1 diabetes presented by renal complications. Background: In patients with type 1 diabetes, an association has been found between an insertion/deletion (I/D) polymorphism in the gene for ACE and the presence of diabetic nephropathy. Methods: A cross section study was conducted on 50 Egyptian children with type 1 diabetes presented by renal complications from our endocrinology, genetic unit and outpatient clinic in pediatric department, Menoufia University, during a period time from April 2021 to October 2022. Results: there was a significant difference between cases and control groups regarding ACE gene polymorphism and its alleles, (P0.05). Conclusion: Our study concluded that ID polymorphism of ACE can markedly increase the incidence of diabetes-related end-stage renal disease. Our data suggests that ACE genes interact in modulating progression of diabetic nephropathy and the individual risk of being a fast progressor in type 1 diabetic patients.

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