Role of Hippo pathway components YAP1, LATS1 in Non-Melanoma Skin Cancer

Authors

Dina Mohamed Allam, Pathology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt.Follow
Rehab Mounir Samaka, Pathology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt
Asmaa Mohamed Shams Eldeen, Pathology Department, Faculty of Medicine Menoufia University, Menoufia, Egypt

Subject Area

Pathology

Article Type

Original Study

Abstract

Background: Non-melanoma skin cancer (NMSC) has a greater lethality with substantial morbidity. Hippo pathway is important for tissue homeostasis. Objectives: To assess the role of YAP1 and LATS1 in Non-melanoma skin cancer (NMSC). Methods: This retrospective case-control study included 70 NMSC specimens (50 BCC and 20 SCC cases) and 40 control cases from Egyptian patients. Immunohistochemical staining of YAP1 and LATS1 was done and assessed semi-quantitatively using staining extent and intensity. The results were correlated with the available clinicopathological parameters. We aimed to evaluate the role of YAP1 & LATS1 in NMSC. Results: Malignant cases showed significant positive epithelial expression for both YAP1 and LATS1 (P

Recommended Citation

Allam, Dina Mohamed; Samaka, Rehab Mounir; and Eldeen, Asmaa Mohamed Shams (2023) "Role of Hippo pathway components YAP1, LATS1 in Non-Melanoma Skin Cancer," Menoufia Medical Journal: Vol. 36: Iss. 3, Article 23.
DOI: https://doi.org/10.59204/2314-6788.1041