Subject Area

Internal Medicine

Document Type

Original Study


Objectives: To determine if the poor diastolic function of the left ventricle was independently correlated with hepatic steatosis and fibrosis in type 2 diabetes mellitus (T2DM). Background: There is growing evidence that it is related to nonalcoholic fatty liver disease (NAFLD) and left ventricular diastolic dysfunction (LVDD). We sought to learn more about the relationship between LV diastolic dysfunction and liver fibrosis in T2DM patients. Methods: a case control study was conducted on 100 patients, 50 of them with type 2 diabetes patients without NAFLD and 50 diabetic patients with NAFLD. NAFLD fibrosis score (NFS) and abdominal ultrasonography were used to determine the presence of NAFLD. In order to detect the presence of left ventricular diastolic dysfunction and determine the ratio of early to late ventricular filling (E/A) and the deceleration time, pulsed-wave Doppler echocardiography was performed. Results: Compared to the non-NAFLD group, the NAFLD group had significantly more left ventricular diastolic dysfunction (64% vs. 40%,) with P=0.011. Conclusions: Non-alcoholic steatosis is associated with early diastolic dysfunction echocardiographic characteristics seen in diabetic patients.