Subject Area


Document Type

Original Study


Objectives: To evaluate the efficacy and safety of intraoperative intravenous injections of Tranexamic Acid on intraoperative and postoperative blood loss and transfusion in Total Knee arthroplasty. Background: Total knee arthroplasty (TKA) is an effective treatment for advanced disease of the knee joint, which can relieve pain and improve joint function. With improvements in surgical techniques and prosthetic design, TKA is a widely used clinical application. Patients and Methods: This study was conducted on 46 patients for total knee arthroplasty (TKA). All patients were divided into 2 groups: group A (25 knees) without intravenous injection of tranexamic acid (control group) and group B group (25 knees) received intravenous injection with tranexamic acid intraoperative. Result: As regard Knee Parameters among the studied groups, we found that the mean preoperative knee ROM was 102 ± 4.2 degrees (range, 95 – 110 degrees) and 102 ± 4.8 degrees (range, 93 – 112 degrees) in group A and group B, respectively. The mean preoperative KSS was 83 ± 7 points (range, 70 – 96 points) and 82 ± 10 points (range, 62 – 100 points) in group A and group B, respectively. Conclusion: The use of TXA has no effect on Knee improvement. These findings of the present study prompt surgeons to consider incorporating the use of TKA to their bloodsaving protocols for patients undergoing TKA, particularly simultaneous bilateral TKAs.